Surname
- John Spikes (1881–1955), American jazz musician and entrepreneur
- Reb Spikes (1888–1982), American jazz saxophonist and entrepreneur
- Robert W. Spike (1923–1966), American clergyman, theologian, and civil rights leader
- Spike (Welsh guitarist), Welsh guitarist
- John Spike (born 1951), American art historian, curator, and author, specializing in the Italian Renaissance and Baroque periods
- Michèle Kahn Spike, American lawyer, historian, and prominent lay figure in the Episcopalian church
- Moondog Spike, professional wrestler
- Paul Spike, American author, editor and journalist
- Brandon Spikes (born 1987), American football linebacker for the New England Patriots of the National Football League (NFL)
- Cameron Spikes (born 1976), former American football guard of the National Football League
- Charlie Spikes (born 1951), Major League Baseball player
- Irving Spikes (born 1970), former professional American football player who played running back for four seasons for the Miami Dolphins
- Jack Spikes (born 1937), former American collegiiate and Professional Football running back and placekicker
- Jesse Spikes (born 1950), corporate lawyer in Atlanta, Georgia, who was a candidate in the 2009 Atlanta mayoral race
- Richard Spikes (1884–1962), African-American engineer from San Francisco, California
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