Role in Neural Stem Cells
In neurogenesis, Sox2 is expressed throughout developing cells in the neural tube as well as in proliferating CNS progenitors. However, Sox2 is downregulated during progenitors' final cell cycle during differentiation when they become post mitotic. Cells expressing Sox2 are capable of both producing cells identical to themselves and differentiated neural cell types, two necessary hallmarks of stem cells. Proliferation of Sox2+ neural stem cells can generate neural precursors as well as Sox2+ neural stem cell population.
Induced pluripotency is possible using adult neural stem cells, which express higher levels of Sox2 and c-Myc than embryonic stem cells. Therefore only two exogenous factors, one of which is necessarily Oct4, are sufficient for inducing pluripotent cells from neural stem cells, lessening the complications and risks associated with introducing multiple factors to induce pluripotency.
Read more about this topic: SOX2
Famous quotes containing the words role in, role, stem and/or cells:
“If women’s role in life is limited solely to housewife/mother, it clearly ends when she can no longer bear more children and the children she has borne leave home.”
—Betty Friedan (20th century)
“Our role is to support anything positive in black life and destroy anything negative that touches it. You have no other reason for being. I don’t understand art for art’s sake. Art is the guts of the people.”
—Elma Lewis (b. 1921)
“Apples? New Hampshire has them, but unsprayed,
With no suspicion in stem end or blossom end
Of vitriol or arsenate of lead,
And so not good for anything but cider.”
—Robert Frost (1874–1963)
“The twelve Cells for Incorrigibles ... are also carved out of the solid rock hill. On the walls of one of the cells human “liberty” is clearly inscribed, with the “liberty” in significant quotation marks.”
—Administration in the State of Ariz, U.S. public relief program (1935-1943)