Types
The two most well known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family.
| Gene | Protein | Acronym | Tissue distribution in proximal tubule |
Na+:Glucose Co-transport ratio |
Contribution to glucose reabsorption (%) |
|---|---|---|---|---|---|
| SLC5A1 | Sodium/GLucose coTransporter 1 |
SGLT1 | S3 segment | 2:1 | 10 |
| SLC5A2 | Sodium/GLucose coTransporter 2 |
SGLT2 | predominately in the S1 and S2 segments |
1:1 | 90 |
Including SGLT1 and SGLT2, there are total seven members in the human protein family SLC5A, several of which may also be sodium-glucose transporters.
Read more about this topic: Sodium-glucose Transport Proteins
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