Hybridization-based Methods
Several applications have been developed that interrogate SNPs by hybridizing complementary DNA probes to the SNP site. The challenge of this approach is reducing cross-hybridization between the allele-specific probes. This challenge is generally overcome by manipulating the hybridization stringency conditions.
Read more about this topic: SNP Genotyping
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“Cold and hunger seem more friendly to my nature than those methods which men have adopted and advise to ward them off.”
—Henry David Thoreau (1817–1862)