Snake H/ACA box small nucleolar RNA refers to a number of very closely related non-coding RNA (ncRNA) genes identified in snakes which have been predicted to be small nucleolar RNAs (snoRNAs). This type of ncRNA is involved in the biogenesis of other small nuclear RNAs and are often referred to as 'guide' RNAs. They are usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.
These snoRNA genes were initially identified in the introns of the cardiotoxin 4 and cobrotoxin genes of the Taiwan cobra (Bungarus multicinctus) and the Taiwan banded krait (Bungarus multicinctus) during sequencing of these genes. These snoRNAs are predicted to act as H/ACA box type methylation guides as they have the predicted hairpin-hinge-hairpin-tail structure and extended regions of complementarity to 5S ribosomal RNA (rRNA).
Famous quotes containing the words snake, box and/or small:
“The great snake lies ever half awake, at the bottom of the pit of the world, curled
In folds of himself until he awakens in hunger and moving his head to right and to left prepares for his hour to devour.”
—T.S. (Thomas Stearns)
“I am no source of honey
So why should they turn on me?
Tomorrow I will be sweet God, I will set them free.
The box is only temporary.”
—Sylvia Plath (1932–1963)
“Children crawl before they walk, walk before they run—each generally a precondition for the other. And with each step they take toward more independence, more mastery of the environment, their mothers take a step away—each a small separation, a small distancing.”
—Lillian Breslow Rubin (20th century)