Snake H/ACA box small nucleolar RNA refers to a number of very closely related non-coding RNA (ncRNA) genes identified in snakes which have been predicted to be small nucleolar RNAs (snoRNAs). This type of ncRNA is involved in the biogenesis of other small nuclear RNAs and are often referred to as 'guide' RNAs. They are usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.
These snoRNA genes were initially identified in the introns of the cardiotoxin 4 and cobrotoxin genes of the Taiwan cobra (Bungarus multicinctus) and the Taiwan banded krait (Bungarus multicinctus) during sequencing of these genes. These snoRNAs are predicted to act as H/ACA box type methylation guides as they have the predicted hairpin-hinge-hairpin-tail structure and extended regions of complementarity to 5S ribosomal RNA (rRNA).
Famous quotes containing the words snake, box and/or small:
“The snake that cannot shed its skin perishes. Likewise those spirits who are prevented from changing their opinions; they cease to be spirits.”
—Friedrich Nietzsche (1844–1900)
“However low and poor the taking Snuff argues a Man to be in his own Stock of Thought, or Means to employ his Brains and his Fingers, yet there is a poorer Creature in the World than He, and this is a Borrower of Snuff; a Fellow that keeps no Box of his own, but is always asking others for a Pinch.”
—Richard Steele (1672–1729)
“Reduce big troubles to small ones, and small ones to nothing.”
—Chinese proverb.