SMAD may refer to:
- Sowjetische Militäradministration in Deutschland
- SMAD (protein) – proteins involved in cell signaling
- R-SMAD – receptor regulated SMAD proteins
- I-SMAD – inhibitory SMAD proteins
- SMAD – a house DJ based in New England.
- SMAD - solvated metal atom dispersion, a method to synthezise very small metal nanoparticles