S&M may refer to:

  • Sadomasochism, a form of physical role-playing
  • S&M (album), a 1999 live music album by Metallica and the San Francisco Symphony Orchestra
  • S&M (Le Shok album), 2001
  • "S&M" (song), by Rihanna from Loud
  • The Sodor & Mainland Railway, a fictional railway in The Railway Series media
  • S&M Airlines, a 1989 punk album by NOFX
  • "S&M", a song by Thin Lizzy from Black Rose: A Rock Legend