The Ski protein is a nuclear protooncoprotein that is associated with tumors at high cellular concentrations. Ski has been shown to interfere with normal cellular functioning by both directly impeding expression of certain genes inside the nucleus of the cell as well as disrupting signaling proteins that activate genes.
Ski negatively regulates transforming growth factor-beta (TGF-beta) by directly interacting with Smads and repressing the transcription of TGF-beta responsive genes. This has been associated with cancer due to the large number of roles that peptide growth factors, of which TGF-beta are a subfamily, play in regulating cellular functions such as cell proliferation, apoptosis, specification, and developmental fate.
The name Ski comes from the Sloan-Kettering Institute where the protein was initially discovered.
Famous quotes containing the words ski and/or protein:
“The goal for all blind skiers is more freedom. You dont have to see where youre going, as long as you go. In skiing, you ski with your legs and not with your eyes. In life, you experience things with your mind and your body. And if youre lacking one of the five senses, you adapt.”
—Lorita Bertraun, Blind American skier. As quoted in WomenSports magazine, p. 29 (January 1976)
“Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.”
—Alfred Gingold, U.S. humorist. Items From Our Catalogue, Tofu Innersoles, Avon Books (1982)