In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors. These synapses are named "silent" because normal AMPA receptor-mediated signaling is not present, rendering the synapse inactive under typical conditions. Silent synapses are typically considered to be immature glutamatergic synapses. As the brain matures, the relative number of silent synapses decreases. However, recent research on hippocampal silent synapses shows that while they may indeed be a developmental landmark in the formation of a synapse, that synapses can be made silent by activity, even once they have acquired AMPA receptors. Thus, silence may be a state that synapses can visit many times during their lifetimes.
Read more about Silent Synapse: Synaptic Transmission, Characteristics, Activation, Controversy
Famous quotes containing the word silent:
“... women learned one important lesson—namely, that it is impossible for the best of men to understand women’s feelings or the humiliation of their position. When they asked us to be silent on our question during the War, and labor for the emancipation of the slave, we did so, and gave five years to his emancipation and enfranchisement.... I was convinced, at the time, that it was the true policy. I am now equally sure that it was a blunder.”
—Elizabeth Cady Stanton (1815–1902)