In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors. These synapses are named "silent" because normal AMPA receptor-mediated signaling is not present, rendering the synapse inactive under typical conditions. Silent synapses are typically considered to be immature glutamatergic synapses. As the brain matures, the relative number of silent synapses decreases. However, recent research on hippocampal silent synapses shows that while they may indeed be a developmental landmark in the formation of a synapse, that synapses can be made silent by activity, even once they have acquired AMPA receptors. Thus, silence may be a state that synapses can visit many times during their lifetimes.
Read more about Silent Synapse: Synaptic Transmission, Characteristics, Activation, Controversy
Famous quotes containing the word silent:
“How insupportable would be the days, if the night with its dews and darkness did not come to restore the drooping world. As the shades begin to gather around us, our primeval instincts are aroused, and we steal forth from our lairs, like the inhabitants of the jungle, in search of those silent and brooding thoughts which are the natural prey of the intellect.”
—Henry David Thoreau (1817–1862)