Binding Proteins
One or more SRP proteins bind to the SRP RNA to assemble the functional SRP. The SRP proteins are named according to their approximate molecular mass measured in kilodalton. Most bacterial SRPs are composed of SRP RNA and SRP54 (also named Ffh for "Fifty-four homolog"). The Archaeal SRP contains proteins SRP54 and SRP19. In eukaryotes, the SRP RNA combines with the imported SRP proteins SRP9/14, SRP19, and SRP68/72 in a region of the nucleolus. This pre-SRP is transported to the cytosol where it binds to protein SRP54. The molecular structures of the free or SRP RNA-bound proteins SRP9/14, SRP19, or SRP54 are known at high resolution.
Read more about this topic: Signal Recognition Particle RNA
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