Sie may refer to:
- Sie (pronoun), a gender-neutral pronoun
- Sie Kensou, a character in the series of fighting games The King of Fighters
- Society of Industrial Engineering, an organization of BS Industrial Engineering students of UPHSD - Calamba
- Staten Island Expressway, an expressway located in Staten Island, New York.
- Serviciul de Informaţii Externe — Foreign Intelligence Service (Romania), the Romanian foreign intelligence agency.
- SIE (file format) accounting file format interchange
People with the surname Sie:
- James Sie (born 1962), American voice actor
- Trish Sie (21st century), Grammy Award-winning American choreographer and director