Immune Control
Lipopolysaccharides trigger the immune system to produce proinflammatory cytokines IL-1, IL-6, and tumor necrosis factor (TNF). These peripherally released cytokines act on the brain via a fast transmission pathway involving primary input through the vagus nerves, and a slow transmission pathway involving cytokines originating from the choroid plexus and circumventricular organs and diffusing into the brain parenchyma by volume transmission. Peripheral cytokines may enter the brain directly. They may also induce the expression of other cytokines in the brain that cause sickness behavior. Acute psychosocial stress enhances the ability of an immune response to trigger both inflammation and behavioral sickness.
Read more about this topic: Sickness Behavior
Famous quotes containing the words immune and/or control:
“The moral immune system of this country has been weakened and attacked, and the AIDS virus is the perfect metaphor for it. The malignant neglect of the last twelve years has led to breakdown of our country’s immune system, environmentally, culturally, politically, spiritually and physically.”
—Barbra Streisand (b. 1942)
“Physical nature lies at our feet shackled with a hundred chains. What of the control of human nature? Do not point to the triumphs of psychiatry, social services or the war against crime. Domination of human nature can only mean the domination of every man by himself.”
—Johan Huizinga (1872–1945)