Medical Significance
Both genera have potent tissue-destroying venoms containing the dermonecrotic agent, sphingomyelinase D, which is otherwise found only in a few pathogenic bacteria. Thus, the venom of Sicariidae is highly necrotic in effect, capable of causing lesions (open sores) as large as a US quarter (about one inch or 25mm in diameter). The wounds take a long time to heal and may require skin grafts. If these open wounds get infected there can be serious consequences. Rarely, the venom is carried by the blood stream to internal organs causing systemic effects. The Chilean recluse (Loxosceles laeta), along with the African species of Sicarius, reportedly have a more potent venom, which results in systemic involvement more often.
Read more about this topic: Sicariidae
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