Shirley M. Tilghman - Research

Research

Tilghman's work in molecular genetics focused on the regulation of genes during development, particularly in the field of genomic imprinting.

During postdoctoral studies at the National Institutes of Health, Tilghman made a number of discoveries while a member of the team which cloned the first mammalian gene. She went on to demonstrate that the globin gene was spliced, a finding that helped confirm some of the revolutionary theories then emerging about gene behavior. She continued to make scientific breakthroughs as an independent investigator at the Institute for Cancer Research in Philadelphia and as an adjunct associate professor of Human Genetics at University of Pennsylvania.

Tilghman went to Princeton University in 1986 as the Howard A. Prior Professor of the Life Sciences. Two years later, she also joined the Howard Hughes Medical Institute as an investigator. She was a leader in the use of mice to understand the behavior of genes by researching the effect of gene insertion in embryonic cells.

In 1998, she took on additional responsibilities as the founding director of Princeton's multi-disciplinary Lewis-Sigler Institute for Integrative Genomics, while continuing to study how male and female genomes are packaged and the consequences of the differences for regulating embryo growth.