SGC may refer to:
- the wine brand: Le Secret des Grands Chefs
- Satellite ground station
- Sega Genesis Collection
- Server gated cryptography
- Soluble guanylate cyclase (sGC)
- Sonic Gems Collection
- Southern Gospel Choir
- Stargate Command
- Structural Genomics Consortium
- ScrewAttack Gaming Convention
- Superannuation Guarantee Charge, see Superannuation in Australia
- Single Global Currency
- Secretary General of the Council