Semon may refer to:
- Larry Semon (1889–1928), American actor, director, producer, and screenwriter during the silent film era
- Mo Chuaroc moccu Neth Semon (fl. c. 600?), an Irish monk and scholar of the Early Middle Ages
- Richard Semon (1859–1918), German zoologist and evolutionary biologist
- Waldo Semon (1898–1999), renowned American inventor born in Demopolis, Alabama
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