Literature
- 2nd Chance (novel), a 2003 novel by James Patterson
- Second Chance, a fictional spacecraft in the Commonwealth Saga by Peter F. Hamilton
- Second Chance: Three Presidents and the Crisis of American Superpower, a 2007 non-fiction book by Zbigniew Brzezinski
- Second Chance (Left Behind: The Kids), a 1998 novel by Jerry B. Jenkins and Tim LaHaye; part of the Left Behind: The Kid series
- Second Chance (novel), a 2004 novel by Danielle Steel
- "Second Chance" (short story), a story by Orson Scott Card
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