Secco is a surname of Italian origin, which means dry. It may refer to:
- Alessio Secco (b. 1970), Italian professional football manager
- Deborah Secco (b. 1979), Brazilian actress
- Louis Secco (b. 1927), Canadian Olympic ice hockey player
Secco is a musical term meaning "dry", "without resonance" or "quick".
Secco or Fresco-secco is a type of mural painting where paint is applied to dry plaster on a wall.
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