Scheele may refer to:
- Carl Wilhelm Scheele (1742–1786), German-Swedish pharmaceutical chemist
- Karin Scheele (b. 1968), Austrian politician; member of the European Parliament since 1999
- Leonard A. Scheele (1907–1993), American physician; Surgeon General of the United States from 1948–56
- Nick Scheele (b. 1944), American businessman; chief operating officer of Ford Motor Company
- Thomas von Scheele (b. 1969), Swedish championship table tennis player
- Scheele (crater), the lunar impact crater
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