History
The first examples of signaling scaffold proteins were receptor tyrosine kinases like epidermal growth factor receptors and platelet-derived growth factor receptor. Upon ligand binding to such receptors, tyrosine autophosphorylation occurs in the receptor’s cytoplasmic domain specifically at sites where SRC homology 2 (SH2)-domain-containing proteins can bind. In this case, the receptor’s cytoplasmic domain acts as a scaffold, recruiting signaling proteins and initially localizing the signaling response to the plasma membrane. The subsequent endocytosis of the activated receptor and its intracellular trafficking further localizes the signal to other specific areas of the cell.
Read more about this topic: Scaffold Protein
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