Filmography
| Year | Title | Role | Other notes |
| 1997 | Miracle in the Woods | Young Lilly | |
| Drive | Carolyn Brody | ||
| 1998 | Blade | Vanessa Brooks | |
| 1999 | The Wood | Alicia | |
| The Best Man | Robin | ||
| Catfish in Black Bean Sauce | Nina | ||
| Life | Daisy | ||
| 2000 | Love & Basketball | Monica Wright, Monica Wright-McCall | |
| Disappearing Acts | Zora Banks | ||
| 2002 | Brown Sugar | Sidney 'Sid' Shaw | |
| 2003 | Out of Time | Ann Merai Harrison | |
| 2004 | Alien vs. Predator | Alexa Woods | |
| 2005 | The Golden Blaze | Monica (voice) | |
| 2006 | Something New | Kenya McQueen | |
| Nip/Tuck | Michelle Landau | recurring role | |
| 2008 | A Raisin in the Sun | Beneatha Younger | |
| The Family That Preys | Andrea Pratt-Bennett | ||
| 2009 | Wonderful World | Khadi | |
| Powder Blue | Diana | ||
| 2009–present | The Cleveland Show | Donna Tubbs (voice) | cast member |
| 2010–present | Family Guy | Donna Tubbs (voice) | various episodes |
| 2011 | Contagion | Aubrey Cheever | |
| 2011 | Night of the Hurricane | Donna Tubbs (voice) |
Read more about this topic: Sanaa Lathan