Ryanodine Receptor - Associated Proteins

Associated Proteins

Many other proteins with various functions are associated with RyR. For instance in RyR2 from luminal side it is calsequestrin which forms quaternary structure of RyR along with junctin and triadin. Calsequestrin has multiple Ca2+ binding sites and binds Ca2+ ions with very low affinty so they can be easily released.

Ryanodine receptors are usually found in clusters of 3 or 4 (i.e. they are associated with each other)and it was observed that they are to some extent able to open and close simultaneously. This happens more often in physiological conditions and is less observed in vitro.