Ruffo may refer to:
- Bruno Ruffo, an Italian motorcycle road racer
- Ernesto Ruffo Appel, an American-born governor of Baja, California
- Fulco Ruffo di Calabria (1884-1946), Italian World War I flying ace
- Fabrizio Ruffo (1744-1827), an Italian cardinal
- Marco Ruffo, an Italian architect
- Paola Ruffo di Calabria, queen consort of Belgium
- Tommaso Ruffo, an Italian cardinal
- Titta Ruffo, an Italian baritone
- Victoria Ruffo, a Mexican actress, sister of Gabriela
- Vincenzo Ruffo, an Italian composer of the Renaissance
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