RTC may refer to:
- Radiative transfer code, a numerical model of radiation in the atmosphere
- Rail tank car
- Rail traffic controller, a person who oversees the movement of trains and controls railway signals
- Rails-to-Trails Conservancy, a US organization to promote use of railroad rights-of-way as trails
- Railway Technical Centre, the British Rail research centre in Derby, England
- Rational Team Concert, an application lifecycle management tool from IBM
- Real-time computing
- Real-time communication is any mode of telecommunications in which all users can exchange information instantly or with negligible latency. In this context, the term "real-time" is synonymous with "live."
- Real-time clock, the clock that keeps the current time while a computer is turned off
- Real-time control
- Redmond Town Center
- Réseau de transport de la Capitale, the regional transportation commission for Quebec City
- Recruit training Command
- Reformed Theological College (Australia)
- Regional Technical College, a type of college in Ireland
- Regional Transportation Commission of Southern Nevada, a government agency that operates the RTC Transit, formerly called Citizens Area Transit (CAT), bus system
- Regional Transportation Commission of Washoe County, a public body responsible for public transit and roads in Northern Nevada
- Religious Technology Center, the corporate body that controls the intellectual property of the Church of Scientology
- Residential treatment center, a live-in health care facility for adolescents with severe psychological, behavioral, and/or substance abuse issues
- Resolution Trust Corporation, the government-owned company created to manage insolvent financial institutions during the US savings and loan crisis
- Responding to Conflict
- Response Time Compensation aka overdrive, a method to speed up LCD reaction time by changing voltage past the intended value for a short time
- Resurrection Through Carnage
- Reston Town Center
- Right To Carry, right to carry concealed weapon for self-defense
- Right to Censor, a World Wrestling Federation (WWF) parody of the Parents Television Council
- Road traffic collision formerly called Road Traffic Accident
- Rochester Telephone Company (disambiguation), one of several telephone companies in the United States
- Rosette terminal complex, a structure in vascular plants that produces cellulose
- Rotterdam Terror Corps, a Dutch gabber-group