Evolution of The Family Members
Phylogenetic analysis reveals that all Robo receptors have evolved from a common ancestral protein, with many subsequent diversification events occurring independently in different lineages. The Robo gene was initially identified in Drosophila and has since been cloned in various species including mice and humans. Drosophila have three Robo receptors: Robo1, Robo2, and Robo3. In vertebrates, four Robo receptors have been identified: Robo1, Robo2, Robo3/Rig-1, and Robo4/Magic Roundabout.
Read more about this topic: Roundabout (gene)
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