Biological Applications
PV-10 was found to cause an observable response in 60 percent of tumors treated, according to researchers in a phase II melanoma study. Locoregional disease control was observed in 75 percent of patients. Also confirmed was a "bystander effect", previously observed in the phase I trial, whereby untreated lesions responded to treatment as well, potentially due to immune system response. These data were based on the interim results of the first 40 patients treated in an 80 patient study.
Rose Bengal is also used in animal models of ischemic stroke (photothrombotic stroke models) in biomedical research. A bolus of the compound is injected into the venous system. Then the region of interest (e.g., the cerebral cortex) is exposed and illuminated by LASER light of 561 nm. A thrombus is formed in the illuminated blood vessels, causing a stroke in the dependent brain tissue.
Rose bengal has been used for 50 years to diagnose liver and eye cancer. It has also been used as an insecticide.
Rose Bengal is being researched as an agent in creating nano sutures. Wounds are painted on both sides with it and then illuminated with an intense light. This links the tiny collagen fibers together sealing the wound. Healing is faster and the seal reduces chances of infection.
Rose Bengal is used in several microbiological media, including Cooke's Rose Bengal agar, to suppress bacterial growth.
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Famous quotes containing the word biological:
“In America every woman has her set of girl-friends; some are cousins, the rest are gained at school. These form a permanent committee who sit on each other’s affairs, who “come out” together, marry and divorce together, and who end as those groups of bustling, heartless well-informed club-women who govern society. Against them the Couple of Ehepaar is helpless and Man in their eyes but a biological interlude.”
—Cyril Connolly (1903–1974)