Others
- Robert L. Holmes, professor of philosophy at the University of Rochester
- Sir Robert Holmes (Royal Navy officer) (1622–1692), English admiral
- Robert Holmes (barrister) (1765–1859), Irish lawyer and nationalist
- Robert Holmes (priest) (1748–1805), English Biblical scholar and Dean of Winchester
- Robert Holmes (astronomer), American amateur astronomer
- Robert Holmes (composer), wrote music for computer games
- Robert Holmes (musician), guitarist for the band 'Til Tuesday
- Robert Holmes (scriptwriter) (1926–1986), English TV scriptwriter
- Robert Holmes (American football) (born 1945), running back for the Kansas City Chiefs and Houston Oilers
- Robert Holmes (footballer) (1867–1955), England & Preston North End footballer
- Bob Holmes (artist) (born 1965), digital art director
- Bobby Holmes (born 1932), Scottish footballer
- Robert Holmes (actor) (1899–1945), British film and theatre actor
- Robert H. Holmes (died 1917), first NYPD African-American officer to die in the line of duty
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