Experimental Manipulation of Splicing
Splicing events can be experimentally altered by binding steric-blocking antisense oligos such as Morpholinos or Peptide nucleic acids to snRNP binding sites, to the branchpoint nucleotide that closes the lariat, or to splice-regulatory element binding sites.
Read more about this topic: RNA Splicing
Famous quotes containing the words experimental and/or manipulation:
“Whenever a man acts purposively, he acts under a belief in some experimental phenomenon. Consequently, the sum of the experimental phenomena that a proposition implies makes up its entire bearing upon human conduct.”
—Charles Sanders Peirce (1839–1914)
“Denotation by means of sounds and markings is a remarkable abstraction. Three letters designate God for me; several lines a million things. How easy becomes the manipulation of the universe here, how evident the concentration of the intellectual world! Language is the dynamics of the spiritual realm. One word of command moves armies; the word liberty entire nations.”
—Novalis [Friedrich Von Hardenberg] (1772–1801)