RNA-binding Protein - RNA-binding Activity and Recognition of The RNA Sequence

RNA-binding Activity and Recognition of The RNA Sequence

RNA-binding proteins exhibit highly specific recognition of their RNA targets by recognizing their sequences and structures. Specific binding of the RNA-binding proteins allow them to distinguish their targets and regulate a variety of cellular functions via control of the generation, maturation, and lifespan of the RNA transcript. This interaction begins during transcription as some RBPs remain bound to RNA until degradation whereas others only transiently bind to RNA to regulate RNA splicing, processing, transport, and localization. In this section, three classes of the most widely studied RNA-binding domains (RNA-recognition motif, double-stranded RNA-binding motif, zinc-finger motif) will be discussed.