RNA-binding Activity and Recognition of The RNA Sequence
RNA-binding proteins exhibit highly specific recognition of their RNA targets by recognizing their sequences and structures. Specific binding of the RNA-binding proteins allow them to distinguish their targets and regulate a variety of cellular functions via control of the generation, maturation, and lifespan of the RNA transcript. This interaction begins during transcription as some RBPs remain bound to RNA until degradation whereas others only transiently bind to RNA to regulate RNA splicing, processing, transport, and localization. In this section, three classes of the most widely studied RNA-binding domains (RNA-recognition motif, double-stranded RNA-binding motif, zinc-finger motif) will be discussed.
Read more about this topic: RNA-binding Protein
Famous quotes containing the words activity, recognition and/or sequence:
“A worm is as good a traveler as a grasshopper or a cricket, and a much wiser settler. With all their activity these do not hop away from drought nor forward to summer. We do not avoid evil by fleeing before it, but by rising above or diving below its plane; as the worm escapes drought and frost by boring a few inches deeper.”
—Henry David Thoreau (1817–1862)
“That the world can be improved and yet must be celebrated as it is are contradictions. The beginning of maturity may be the recognition that both are true.”
—William Stott (b. 1940)
“We have defined a story as a narrative of events arranged in their time-sequence. A plot is also a narrative of events, the emphasis falling on causality. “The king died and then the queen died” is a story. “The king died, and then the queen died of grief” is a plot. The time sequence is preserved, but the sense of causality overshadows it.”
—E.M. (Edward Morgan)