RIS may refer to:
- Radio Information Service, a reading service for the blind in Pittsburgh, Pennsylvania
- Radiology Information System, device used to manipulate and distribute patient radiological data imagery
- Rail Integration System, a feature on many modern-day guns which allows for sights and scopes to be "snapped in"
- Relational Interface System, a database access interface
- Remote Installation Services, a Microsoft Windows service that allows a remote server to act as a custom installation disk
- Reparto Informazioni e Sicurezza, a military intelligence agency of Italy, see SIOS
- Republik Indonesia Serikat (The Republic of the United States of Indonesia)
- Réseau Info-Sports, the original name of RDS Info, a sports broadcaster in Canada
- Reservoir Induced Seismicity
- Reverse image search (TinEye engine)
- Reviving the Islamic Spirit, a major annual Islamic conference in Canada
- RIS (file format), (from Reference Information Systems), a standardized bibliographic data file format
- RIS Delitti Imperfetti, an Italian television series
- Reparto Investigazioni Scientifiche, (en. "Scientific Investigation Section"), the forensic science unit of the Arma dei Carabinieri
- R. I. S. – Die Sprache der Toten, a German television series
- R.I.S, police scientifique, a French television series
- Rishton railway station, England; National Rail station code RIS
- Roosevelt Intermediate School, an Intermediate School in Westfield, New Jersey
- Routing Information Service project of RIPE NCC
- Ruamrudee International School, an International School located in Bangkok, Thailand
- Russian Imperial Stout, a type of dark beer
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