Reye's Syndrome - Signs and Symptoms

Signs and Symptoms

Reye's syndrome progresses through five stages:

  • Stage I
    • Rash on palms of hands and feet
    • Persistent, heavy vomiting that is not relieved by not eating
    • Generalized lethargy
    • Confusion
    • Nightmares
    • High fever
    • Headaches
  • Stage II
    • Stupor caused by encephalitis
    • Hyperventilation
    • Fatty liver (found by biopsy)
    • Hyperactive reflexes
  • Stage III
    • Continuation of Stage I and II symptoms
    • Possible coma
    • Possible cerebral oedema
    • Rarely, respiratory arrest
  • Stage IV
    • Deepening coma
    • Dilated pupils with minimal response to light
    • Minimal but still present hepatic dysfunction
  • Stage V
    • Very rapid onset following stage IV
    • Deep coma
    • Seizures
    • Multiple organ failure
    • Flaccidity
    • Hyperammonemia (above 300 mg/dL of blood)
    • Death

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