Etiology
The etiology of RAS is not clear cut. Several causes have been speculated including a capillary leak syndrome from cytokine release from the differentiating myeloid cells. Alternatively, ATRA may cause the maturing myeloid cells to acquire the ability to infiltrate organs such as the lung.
Mediation by cathepsin G has been suggested.
Read more about this topic: Retinoic Acid Syndrome