Plot
Six years after the events of Resident Evil 2, former Raccoon City police officer Leon Scott Kennedy is sent on a mission to rescue Ashley Graham, the U.S. President's daughter, who has been kidnapped by a mysterious cult. He travels to a rural village in Europe, where he encounters a group of hostile villagers who pledge their lives to Los Illuminados ("The Enlightened Ones" in Spanish), the cult that kidnapped Ashley.
While in the village, Leon is captured by its chief, Bitores Mendez, and injected with a mind-controlling parasite known as Las Plagas. He finds himself held captive with Luis Sera, a former Los Illuminados researcher. The two work together to escape, but then quickly go their separate ways. Leon discovers that Ashley is being held in a chapel, and rescues her. They both escape from the chapel after Osmund Saddler, leader of the Illuminados, reveals his plan to use the Plagas they injected into Ashley to cause a disaster in the United States once she returns home. Leon and Ashley try to take refuge in a castle, but are attacked by more Illuminados under the command of Ramon Salazar, another of Saddler's servants. The two are separated from each other by Salazar's traps. Meanwhile, Luis searches for the pills to slow Leon and Ashley's infection, as well as a sample of Las Plagas. He brings the two items to Leon but is killed by Saddler, who takes the sample, while the pills to suppress the infection remain in Leon's hands. While in the castle, Leon briefly encounters Ada Wong, a woman from his past who supports him during his mission. He then battles his way through the castle before finally killing Salazar.
Afterwards, Leon travels to a nearby island research facility, where he continues the search for Ashley. He soon discovers that one of his former training comrades, Jack Krauser (who was believed to have been killed in a helicopter crash two years prior) is responsible for Ashley's kidnapping. It is eventually revealed that both Ada and Krauser are working with Albert Wesker, for whom both intend to secure a Plagas sample. Suspicious of the mercenary's intentions, Saddler orders Krauser to kill Leon, believing that no matter which one dies, he will benefit. After Krauser's defeat, Leon rescues Ashley, and they remove the Plagas from their bodies using a specialized radiotherapeutic device. Leon finally confronts Saddler, and with Ada's help, manages to kill him. However, Ada takes the sample from Leon at gunpoint before escaping in a helicopter, leaving Leon and Ashley to escape via her jet-ski as the island self-destructs.
Read more about this topic: Resident Evil 4
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