Research Into Centenarians - Biochemical Factors

Biochemical Factors

Research carried out in Italy suggests that healthy centenarians have high levels of vitamin A and vitamin E and that this seems to be important in guaranteeing their extreme longevity. Other research contradicts this and has found that these findings do not apply to centenarians from Sardinia, for whom other factors probably play a more important role. A preliminary study carried out in Poland showed that, in comparison with young healthy female adults, centenarians living in Upper Silesia had significantly higher red blood cell glutathione reductase and catalase activities and higher, although insignificantly, serum levels of vitamin E. Researchers in Denmark have also found that centenarians exhibit a high activity of glutathione reductase in red blood cells. In this study, those centenarians having the best cognitive and physical functional capacity tended to have the highest activity of this enzyme.

Some research suggests that low levels of vitamin D may be associated with longevity.

Other research has found that people having parents who became centenarians have an increased number of naïve B-cells.

It is believed that centenarians possess a different adiponectin isoform pattern and have a favorable metabolic phenotype in comparison with elderly individuals.