Reissert Indole Synthesis
The Reissert indole synthesis is a series of chemical reactions designed to synthesize indole or substituted-indoles (4 and 5) from ortho-nitrotoluene 1 and diethyl oxalate 2.
Potassium ethoxide has been shown to give better results than sodium ethoxide.
Read more about Reissert Indole Synthesis: Reaction Mechanism
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“In order to begin an analysis, there must already be a synthesis present in the mind.”
—Johan Huizinga (1872–1945)