One-sided Cut-off Values
In many cases, only one side of the range is usually of interest, such as with markers of pathology including cancer antigen 19-9, where it is generally without any clinical significance to have a value below what is usual in the population. Therefore, such targets are often given with only one limit of the reference range given, and, strictly, such values are rather cut-off values or threshold values.
They may represent both standard ranges and optimal health ranges. Also, they may represent an appropriate value to distinguish healthy person from a specific disease, although this gives additional variability by different diseases being distinguished. For example, for NT-proBNP, a lower cut-off value is used in distinguishing healthy babies from those with acyanotic heart disease, compared to the cut-off value used in distinguishing healthy babies from those with congenital nonspherocytic anemia.
Read more about this topic: Reference Range
Famous quotes containing the word values:
“During our twenties...we act toward the new adulthood the way sociologists tell us new waves of immigrants acted on becoming Americans: we adopt the host culture’s values in an exaggerated and rigid fashion until we can rethink them and make them our own. Our idea of what adults are and what we’re supposed to be is composed of outdated childhood concepts brought forward.”
—Roger Gould (20th century)