Kinase Activity
In biochemistry, a kinase is a type of enzyme that transfers phosphate groups (see below) from high-energy donor molecules, such as ATP (see below) to specific target molecules (substrates); the process is termed phosphorylation. The opposite, an enzyme that removes phosphate groups from targets, is known as a phosphatase. Kinase enzymes that specifically phosphorylate tyrosine amino acids are termed tyrosine kinases.
-
Phosphate -
ATP -
Tyrosine
When a growth factor binds to the extracellular domain of an RTK, its dimerization is triggered with other adjacent RTKs. Dimerization leads to a rapid activation of the protein's cytoplasmic kinase domains, the first substrate for these domains being the receptor itself. The activated receptor as a result then becomes autophosphorylated on multiple specific intracellular tyrosine residues.
Read more about this topic: Receptor Tyrosine Kinases
Famous quotes containing the word activity:
“Genghis Khan, in his usual jodhpurs accessorized with whip, straddled a canvas chair and gloated upon the fairyland he had built. Journalists, photographers, secretaries, sycophants, script girls, and set dressers milled and stirred around him, activity ... irresistibly reminiscent of the movement of maggots upon rotting meat.”
—Angela Carter (1940–1992)