Rab (G-protein) - Types of Rab Proteins

Types of Rab Proteins

There are approximately 70 different Rabs that have been identified in humans thus far. They are mostly involved in vesicle trafficking. Their complexity can be understood if thought of as address labels for vesicle trafficking, defining the identity and routing of vesicles.

Name Subcellular location
RAB1 (YPT1) ER, golgi complex
RAB2 ER, cis-golgi network
RAB3A secretory and synaptic vesicles
RAB4 early endosomes
RAB5A clathrin-coated vesicles, plasma membranes
RAB5C early endosomes
RAB6 medial- and trans-golgi network
RAB7 late endosomes
RAB8 basolateral secretory vesicles
RAB9 late endosome, trans-golgi network
RAB11 recycling endosomes
RAB18 lipid droplets, golgi, endoplasmic reticulum
RAB39a binds Caspase-1 in inflammasome
SEC4 secretory vesicles

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