Types of Rab Proteins
There are approximately 70 different Rabs that have been identified in humans thus far. They are mostly involved in vesicle trafficking. Their complexity can be understood if thought of as address labels for vesicle trafficking, defining the identity and routing of vesicles.
| Name | Subcellular location |
|---|---|
| RAB1 (YPT1) | ER, golgi complex |
| RAB2 | ER, cis-golgi network |
| RAB3A | secretory and synaptic vesicles |
| RAB4 | early endosomes |
| RAB5A | clathrin-coated vesicles, plasma membranes |
| RAB5C | early endosomes |
| RAB6 | medial- and trans-golgi network |
| RAB7 | late endosomes |
| RAB8 | basolateral secretory vesicles |
| RAB9 | late endosome, trans-golgi network |
| RAB11 | recycling endosomes |
| RAB18 | lipid droplets, golgi, endoplasmic reticulum |
| RAB39a | binds Caspase-1 in inflammasome |
| SEC4 | secretory vesicles |
Read more about this topic: Rab (G-protein)
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