Quigley is a surname of Irish origin anglicised from the Gaelic Ó Coigligh meaning 'descendent of Coigleach (male)' or Ní Choigligh meaning 'descendent of Coigleach (female)' that may refer to:
- Brett Quigley (born 1969), American golfer on the PGA tour
- Carroll Quigley (1910–1977), American writer and history professor
- Dana Quigley (born 1947), American golfer on the Champions tour
- Dennis Quigley (1913–1984), Scottish footballer
- Derek Quigley (born 1932), New Zealand politician
- Eddie Quigley (c. 1921–1997), English footballer
- Ernie Quigley (1880–1960), Canadian-American sports official
- James Edward Quigley (1854–1915), Canadian-American religious figure who served as Archbishop of Chicago
- Jane Quigley (born 1939), American actress
- Jez Quigley, a character on the British soap opera Coronation Street
- Joan Quigley (born 1927), American astrologer
- Joan M. Quigley (born 1940), American politician from New Jersey
- John Quigley (disambiguation), several people
- Johnny Quigley (1935–2004), Scottish footballer for Nottingham Forest
- Joy Quigley (born 1948), New Zealand politician
- Linnea Quigley (born 1958), American B-movie actress
- Maggie Quigley (born 1979), American actress
- Matthew Quigley, fictional character in the film Quigley Down Under
- Michael Quigley (politician), American politician from Illinois
- Mike Quigley (footballer), English footballer
- Sheila Quigley (born 1948?), English novelist
- Thomas J. Quigley (1905–1960), American superintendent of Catholic schools
- William P. Quigley, law professor and research director at Loyola University New Orleans