Qube may refer to:
- QUBE, a former cable television system
- Qube Software, makers of 3D software Q (game engine)
- QubeTV, a conservative video website
- Cobalt Qube, a server appliance
- Intelligent Qube, a 1997 puzzle video game
- Q.U.B.E., a 2011 puzzle video game
- The Qube, Quicken Loans office building in Detroit
- Qube (building), a distinctive "hanging" building in Vancouver, BC, Canada
- Qube Logistics, an Australian transport company