Pyruvate Dehydrogenase Complex - Structure & Function in Eukaryotes

Structure & Function in Eukaryotes

Pyruvate dehydrogenase complex is organized in cubic symmetry in prokaryotes, having 60 subunits in three functional proteins. Pyruvate dehydrogenase complex is located in the mitochondrial matrix of eukaryotes. It is organized in dodecahedral symmetry, and consists of a total of 96 subunits, organized into three functional proteins in the human enzyme:

Enzyme Abbrev. Cofactor(s) # subunits prokaryotes # subunits eukaryotes
pyruvate dehydrogenase
(EC 1.2.4.1)
E1 TPP (thiamine pyrophosphate) 24 30
dihydrolipoyl transacetylase
(EC 2.3.1.12)
E2 lipoate
coenzyme A
24 60
dihydrolipoyl dehydrogenase
(EC 1.8.1.4)
E3 FAD
NAD+
12 12

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