Structure & Function in Eukaryotes
Pyruvate dehydrogenase complex is organized in cubic symmetry in prokaryotes, having 60 subunits in three functional proteins. Pyruvate dehydrogenase complex is located in the mitochondrial matrix of eukaryotes. It is organized in dodecahedral symmetry, and consists of a total of 96 subunits, organized into three functional proteins in the human enzyme:
| Enzyme | Abbrev. | Cofactor(s) | # subunits prokaryotes | # subunits eukaryotes |
|---|---|---|---|---|
| pyruvate dehydrogenase (EC 1.2.4.1) |
E1 | TPP (thiamine pyrophosphate) | 24 | 30 |
| dihydrolipoyl transacetylase (EC 2.3.1.12) |
E2 | lipoate coenzyme A |
24 | 60 |
| dihydrolipoyl dehydrogenase (EC 1.8.1.4) |
E3 | FAD NAD+ |
12 | 12 |
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