Structure & Function in Eukaryotes
Pyruvate dehydrogenase complex is organized in cubic symmetry in prokaryotes, having 60 subunits in three functional proteins. Pyruvate dehydrogenase complex is located in the mitochondrial matrix of eukaryotes. It is organized in dodecahedral symmetry, and consists of a total of 96 subunits, organized into three functional proteins in the human enzyme:
| Enzyme | Abbrev. | Cofactor(s) | # subunits prokaryotes | # subunits eukaryotes |
|---|---|---|---|---|
| pyruvate dehydrogenase (EC 1.2.4.1) |
E1 | TPP (thiamine pyrophosphate) | 24 | 30 |
| dihydrolipoyl transacetylase (EC 2.3.1.12) |
E2 | lipoate coenzyme A |
24 | 60 |
| dihydrolipoyl dehydrogenase (EC 1.8.1.4) |
E3 | FAD NAD+ |
12 | 12 |
Read more about this topic: Pyruvate Dehydrogenase Complex
Famous quotes containing the words structure and/or function:
“The structure was designed by an old sea captain who believed that the world would end in a flood. He built a home in the traditional shape of the Ark, inverted, with the roof forming the hull of the proposed vessel. The builder expected that the deluge would cause the house to topple and then reverse itself, floating away on its roof until it should land on some new Ararat.”
—For the State of New Jersey, U.S. public relief program (1935-1943)
“The fact remains that the human being in early childhood learns to consider one or the other aspect of bodily function as evil, shameful, or unsafe. There is not a culture which does not use a combination of these devils to develop, by way of counterpoint, its own style of faith, pride, certainty, and initiative.”
—Erik H. Erikson (1904–1994)