PUC or P.U.C. may refer to:
- Pacific Union College
- Pathé Unlimited Card, a pass for unlimited entrance at all Pathé movie theaters in the Netherlands
- Personal Unblocking Code
- Pollution Under Control certificate
- Postal Union Congress, a meeting of the Universal Postal Union
- Pontifícia Universidade Católica (disambiguation)
- Pontificia Universidad Católica de Chile
- Pre University Course
- Presidential Unit Citation, an award bestowed to military units
- Public Utilities Commission
- Purdue University Calumet
- pUC19, (p short for "plasmid," UC short for "University of California"), a bacterial plasmid used in molecular cloning and other molecular biology applications
- Personal and Ubiquitous Computing, a scientific journal published by Springer Science+Business Media
- Plan Unico de Cuentas Colombia
- Paris Université Club, rugby union club in Paris, France
- Paris Université Club, baseball club in Paris, France