Psy may refer to:
- Psy (entertainer), South Korean rapper best known for his single "Gangnam Style"
- Psy, a rapper from the Oddities, and The Nope
- Psychedelic trance or simply psy, a form of electronic music
- Psy (film), a 1992 film directed by Wladyslaw Pasikowski
- Simon "Psy" Kaina, a character in the manga and anime Heroman
- ISO 639-3 code for the Piscataway language, an extinct Native American language