Proton ATPase

Proton ATPase

In the field of enzymology, the proton-ATPase (EC 3.6.3.6) is an enzyme that catalyzes the following chemical reaction:

ATP + H
2O + H+
_in ADP + phosphate + H+
_out

The 3 substrates of this enzyme are ATP, H
2O, and H+
, whereas its 3 products are ADP, phosphate, and H+
.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. To be specific, the protein is a part of the P-type ATPase family. The systematic name of this enzyme class is ATP phosphohydrolase (H+
-exporting).

H+
-exporting ATPase is also known as proton ATPase or more simply proton pump. Other names in common use include proton-translocating ATPase, yeast plasma membrane H+
-ATPase, yeast plasma membrane ATPase, and ATP phosphohydrolase.