History
Protein splicing was reported by two groups (Anraku and Stevens) in 1990. They both discovered a Saccharomyces cerevisiae VMA1 in a precursor of a vacuolar H+-ATPase. The amino acid sequence of the N- and C-termini corresponded to 70% of that of a vacuolar H+-ATPase from other organisms, while the amino acid sequence of the central position corresponded to 30% of that of the yeast HO nuclease
Read more about this topic: Protein Splicing
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