Protein P16 Pathway
Protein p16 pathway mechanism in cell cycle begins when cyclin D which is a kinase activator binds itself to CDK4/ CDK6. upon the interaction CDK undergoes conformational change and the complex formed triggers pRB phosphorylation. then, pRB which undergoes conformational change and is now functionally inactivated since its size, shape and charge is different hence it can not fit as before. However, the phosphorylated pRB releases a transcription factor E2F that causes induction of p16 expression. Then, pl6 proceeds to bind all CDK4/CDK6 hence, cyclin D is no longer protected by association with its CDK4/CDK6 partner.p16 appears in many pathway mechanisms including DNA damage checkpoint, G1/S checkpoint and many others.
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