Protein Kinase - Tyrosine-specific Protein Kinases

Tyrosine-specific Protein Kinases

Tyrosine-specific protein kinases (EC and EC phosphorylate tyrosine amino acid residues, and like serine/threonine-specific kinases are used in signal transduction. They act primarily as growth factor receptors and in downstream signaling from growth factors; some examples:

  • Platelet-derived growth factor receptor (PDGFR)
  • Epidermal growth factor receptor (EGFR)
  • Insulin receptor and insulin-like growth factor 1 receptor (IGF1R)
  • Stem cell factor (SCF) receptor (also called c-kit, see the article on gastrointestinal stromal tumor).

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