Termination
Termination of DNA replication in E. coli is completed through the use of termination sequences and the Tus protein. These sequences allow the two replication forks to pass through in only one direction, but not the other.
DNA replication initially produces two catenated or linked circular DNA duplexes, each comprising one parental strand and one newly synthesised strand (by nature of semiconservative replication). This catenation can be visualised as two interlinked rings which cannot be separated. Topoisomerase IV in E. coli unlinks or decatenates the two circular DNA duplexes.
Read more about this topic: Prokaryotic DNA Replication
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“We hoped for a happy termination of this terrible war long before this; but God knows best, and has ruled otherwise.”
—Abraham Lincoln (1809–1865)