Prokaryotic Cytoskeleton - Bactofilin

Bactofilin

Bactofilin is a cytoskeletal element that forms filaments throughout the cells of the rod-shaped proteobacterium Myxococcus xanthus. The bactofilin protein, BacM, is required for proper cell shape maintenance and cell wall integrity. M. xanthus cells lacking BacM have a deformed morphology characterized by a bent cell body, and bacM mutants have decreased resistance to antibiotics targeting the bacterial cell wall. M. xanthus BacM protein is cleaved from its full-length form to allow polymerization. Bactofilins have been implicated in cell shape regulation in other bacteria, including curvature of Proteus mirabilis cells, stalk formation by Caulobacter crescentus, and helical shape of Helicobacter pylori.

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