Professor Moriarty
Professor James Moriarty is the archenemy of Sherlock Holmes, a fictional detective created by Sir Arthur Conan Doyle. Moriarty is a criminal mastermind whom Holmes describes as the "Napoleon of crime". Doyle lifted the phrase from a real Scotland Yard inspector who was referring to Adam Worth, one of the real life models of Moriarty. The character of Moriarty as Holmes's greatest enemy was introduced primarily as a narrative device to enable Conan Doyle to kill off Sherlock Holmes, and only featured directly in two of the Sherlock Holmes stories. However, in more recent derivative work he is often given a greater prominence and treated as Holmes's primary antagonist.
Read more about Professor Moriarty: Appearance in Doyle's Fiction, Personality, Moriarty's Family and First Name, Simon Newcomb and Other Real World Role Models
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“All his works might well enough be embraced under the title of one of them, a good specimen brick, “On Heroes, Hero-Worship, and the Heroic in History.” Of this department he is the Chief Professor in the World’s University, and even leaves Plutarch behind.”
—Henry David Thoreau (1817–1862)